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AstraZeneca's shares fell 8.4% on the London Stock Exchange amid concerns over a Chinese investigation into alleged aggressive sales tactics for its oncology drugs, Tagrisso and Imjudo. The company's local president, Leon Wang, is under investigation, signaling increased scrutiny from Beijing. Despite the turmoil, AstraZeneca aims for $80 billion in sales by 2030, up from $45.8 billion in 2023, with plans to launch 20 new drugs by the decade's end.
23andMe faces potential bankruptcy, raising concerns over the fate of customer DNA data, particularly for Swiss users, where genetic data is generally well protected. Despite claims of data security, the company’s policies allow for data sale during acquisitions, and past breaches have compromised sensitive information. With a significant drop in value and management turmoil, the future of 23andMe and its handling of genetic data remains uncertain.
UBS has maintained a 'Neutral' rating for GSK, setting a target price of 1580 pence. Analyst Jo Walton has slightly increased his 2025 estimates but expresses skepticism about the outlook for the Shingrix vaccine in China starting in 2026.
GSK's vaccine sales plummeted in the third quarter, with shingles vaccine sales down 7% and respiratory syncytial virus (RSV) shot Arexvy dropping 72% year over year. The decline is attributed to a narrower CDC recommendation, prioritization of COVID vaccinations, and lower RSV infection rates. GSK anticipates a low single-digit decline in overall vaccine sales for the year.
GSK Plc reported a decline in sales for two of its major vaccines in the third quarter, attributed to access issues in the US. Arexvy, for respiratory syncytial virus, generated £188 million, falling short of the £290 million forecast, while Shingrix sales reached £739 million, below the expected £895 million.
European markets are set to open lower, influenced by the EU's decision to raise tariffs on Chinese electric vehicles, with stocks like Nio and Geely experiencing declines. The U.K. is poised to reveal its first budget in 14 years, while investors are eyeing potential impacts on various stocks. Additionally, analysts suggest that the dollar may weaken under a Trump presidency, despite initial expectations of a stronger currency.
GSK Plc has acquired an experimental drug from Chinese biotech firm Chimagen Biosciences for up to $850 million, enhancing its lupus treatment pipeline. The deal includes a $300 million upfront payment, with Chimagen eligible for up to $550 million in success-based milestones. The antibody drug, currently in early clinical trials for leukemia and lymphoma, is set to enter early trials for lupus in 2025.
Lyell Immunopharma is acquiring cell therapy startup ImmPact Bio for $30 million in cash and 37.5 million shares, with potential additional shares based on milestones. The company is streamlining its research focus on differentiated cellular immunotherapies for cancer, including the promising IMPT-314 therapy for blood cancers, while halting less successful projects. Following challenges since its IPO, Lyell aims for a turnaround with a financial runway extending into 2027.
The CDC's advisory panel has recommended lowering the routine pneumococcal vaccination age from 65 to 50, potentially expanding the market for vaccines like Merck's Capvaxive and Pfizer's Prevnar. Analysts have adjusted sales forecasts, anticipating significant revenue growth for these vaccines, particularly for Merck in the near term, though competition from Vaxcyte's candidate may emerge by 2028.
The FDA has expanded the approval of Pfizer’s RSV vaccine, Abrysvo, to include adults aged 18 to 59 years at increased risk of respiratory syncytial virus, in addition to those aged 60 and older and pregnant women. Despite three available vaccines, uptake remains slow, partly due to CDC recommendations focusing on higher-risk individuals over 75. GSK has also received expanded approval for its RSV vaccine, Arexvy, for adults aged 50 to 59.

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